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Ellis Fischel Cancer Center and MD Anderson

Clinical Trials

If you have any questions or concerns please contact Ken Baker at 573-884-6479

Through the clinical trials program at Ellis Fischel Cancer Center, patients might have access to treatments years before they become widely available. "The reason we are where we are today is because of clinical trials," said C. Daniel Kingsley, MD, FACP, Ellis Fischel oncologist and director of the trials program. "For some patients, these treatments are game changers because having that access a year or even two years before anyone else can make a huge difference for a cancer patient. You are giving them a head start." For Dr. Kingsley, imagining a world without cancer means a future where treatments for each patient become even more personalized.

"I can see a future where we can examine your specific cancer, then examine its gene expression and tailor the treatment specifically to the genetic makeup. Maybe it’s a vaccine or maybe it’s antibodies, but we are getting closer to a world of personalized treatments." Even if we never reach a perfect world without cancer, Dr. Kingsley said he can envision a world where the survival rates for cancer improve and treatments become less toxic to the body. Right now, he’s proud of the work going on at Ellis Fischel.

"We have an incredible amount of brain power under one roof to create the best treatment plan for each patient," Kingsley said. "Not only that, but we are collaborating with researchers across the University of Missouri campus to better understand the how cancer behaves and reacts to treatments."

Clinical trials are research studies that involve people. They are the final step in a long process that begins with research in a lab and animal testing. Many treatments used today are the result of past clinical trials.

Ellis Fischel Cancer Center physicians and staff ensure that all of our patients receive the best care. This means if we ask you or a loved one to participate in a clinical trial, we have good reason to believe that the new treatment(s) will help and we see promise and potential in the new treatment options. These new treatments could become the new standard of care and we want only the best for our patients.


**No Trials Available at this time.


  • Esiai Inc-E7389-A001-303: A Randomized Phase III Trial of Eribulin Compared to Standard Weekly Paclitaxel as First- or Second-line Therapy for locally Recurrent or Metastatic Breast Cancer. NCT# 02037529

  • ECOG 2112 A Randomized Phase III Trial of Endocrine Therapy + Entinostat/Placebo in Postmenopausal Patients w/ Hormone Receptor-Positive Advanced Breast Cancer. NCT# 02115282

  • A011106: Alternate approaches for clinical stage II or III Estrogen Receptor Positive Breast Cancer Neoadjuvant Treatment (ALTERNATE) in Postmenopausal women: A Phase III Study. NCT# 01953588

  • S1207; Phase III Randomized, Controlled-Placebo Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy+/-One Year of Everolimus in Patients w/High-Risk, Hormone Receptor-Positive & HER2/neu Negative Breast Cancer. NCT# 01674140

  • NGR-BR003: Phase III Dose-Dense Adjuvant AC followed by weekly Taxol+/-Carboplatin for node-positive or high risk nose-neg HER2-neg, ER-neg, and PR-neg invasive (unilateral) BC NCT #02488967 

Cancer Control

**No Trials Available at this time.

Gastrointestinal (GI)

**No Trials Available at this time.

Genitourinary GU


  • SWOG S1216: A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 w/Androgen Deprivation Therapy + Bicalutamide in Patients w/Newly Diagnosed Metastatic Hormone Sensitive Prostate Cancer. NCT# 01809691
  • CIRB-A031201: Phase II of Enzalutamide (NSC#766085) vs. Enzalutamide, Abiraterone & Prednisone for Castration Resistant Metastatic Prostate Cancer. NCT# 01949337

Renal Carcinoma

  • CTSU-E2810: Randomized, Double-Blind Phase Ill Study of Pazopanib vs. Placebo in Patients with Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease Following Metastatectomy  NCT #01575548

Gynecological Oncology (GYN)

Ovarian Cancer

  • NRG-GY005: Randomized Phase 11/III study of the combination of cediranib and olaparid compared to cediranib or olaparib alone, or SOC chemotherapy in recurrent platinum­ resistant/refractory ovarian, fallopian tube, or primary peritoneal cancer NCT#02502266

  • Janssen OVC-3006: A Randomized, Open-Label Study Comparing the Combination of YONDELIS and DOXIL with DOXIL Monotherapy for the treatment of Advanced-Relapsed Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer NCT#01846611

  • GOG-Foundation-3005/AbbVi e-M13-694: A Phase 3 Placebo-Controlled Study of Carboplatin/P.aclitaxel With or Without Concurrent and Continuation Maintenance Veliparib (PARP Inhibitor) in Subjects with Previously Untreated Stages Ill or IV High-Grade Serous Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer NCT#02470585

Head and Neck, Supportive Care

  • Galera-GT-201; Randomized Phase II double-blind trial of2 doses ofIV GC4419 vs placebo (1:1:1 randomization) to reduce the incidence and duration of oral mucositis during post-op or definitive therapy with single agent cisplatin + IMRT NCT#02508389 



  • Celgene-CC 5013-NHL-008: Phase 3b Randomized Studyof Lenalidomide (CC-5013) PlusRituximab Maintenance Therapy Followed by Lenalidomide Single-Agent Maintenance Versus Rituximab Maintenance in Subjects with Relapsed/Refractory Follicular, Marginal Zone or Mantle Cell Lymphoma. NCT# 01996865 
  • Genentech G029834 Harmony :A Phase lb/II Study Evaluating the Safety and Efficacy of Obinutuzumab in Combination with Polatuzumab Vedotin and Lenalidomide in Patients with Relapsed or Refractory Follicular or Diffuse Large B-Cell Lymphoma (currently enrolling only to Follicular Lymphoma cohorts) NCT# 02600897

  • NCl-MATCH/EAY1 31:Molecular Analysis for Therapy Choice Phase II trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. NCT#02465060

  • CTSU-ECOG E1411:Intergroup Randomized Phase II Four Arm Study In Patients Greater Than or Equal to 60 With Previously Untreated Mantle Cell Lymphoma Of Therapy With: Arm A = Rituximab + Bendamustine Followed By Rituximab Consolidation (RB → R); Arm B = Rituximab + Bendamustine + Bortezomib Followed By Rituximab Consolidation (RBV→ R), Arm C = Rituximab + Bendamustine Followed By Lenalidomide + Rituximab Consolidation (RB →LR) or Arm D = Rituximab + Bendamustine + Bortezomib Followed By Lenalidomide + Rituximab Consolidation (RBV→ LR) NCT#01415752



  • Gilead Sciences Inc GS US 339 0102: Phase 2, Open-Label Study Evaluating the Efficacy, Safety, Tolerability, and Pharmacodynamics ofGS-9973 in Subjects with Relapsed or Refractory Hematologic Malignancies *(Now open only for Clironic Lymphocytic Leukemia that has recurred after ibrutinib and/or idelalisib therapy) NCT# 01799889 


Squamous Cell

  • SWOG S1400; Phase II/III Biomarker-Driven Master Protocol for 2nd line Therapy of Squamous Cell Lung Cancer. NCT# 02154490 



  • CIRB - SWOG 1320: Randomized Phase II Trial of Intermittent Versus Continuous Dosing of Dabrafenib (NSC-763760) & Trametinib (NSC-763093) in BRAF V600E/K Mutant Melanoma NCT# 02196181

Multiple Myeloma

  • CTSU-ECOG-ACRIN-E1A11: Randomized Phase Ill Trial of Bortezomib, LENalidomide and Dexamethasone (VRd) Versus Carfilzomib, Lenalidomide and Dexamethasone (CRd) Followed by Limited or Indefinite DURation Lenalidomide MaintenANCE in Patients with Newly Diagnosed Symptomatic Multiple Myeloma (ENDURANCE) NCT#01863550

Solid Tumors

  • NCl-MATCH/EAY131: Phase II trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. NCT# 02465060

Why Have Clinical Trials?

In cancer, clinical trials are designed to answer questions about new ways to:

  • Treat Cancer
  • Find and diagnose cancer
  • Prevent cancer
  • Manage symptoms of cancer or side effects from its treatment

Studies are designed to answer questions about new treatments or ways of using an existing treatment better.  These trials test many types of treatments, such as new:

  • Drugs or vaccines
  • Ways to do surgery or give radiation therapy
  • Combinations of treatments

Please visit the following link for more information from the National Cancer Institute (NCI) about Clinical Trials: