Taste Changes With Bariatric Surgery

The overall goal of the present project is to determine the magnitude of taste changes to sweet tastants in subjects who have undergone bariatric surgery. Taste perception will be assessed before surgery (pre-operative, pre-op) and after bariatric surgery, at approximately 1 month. Taste studies will be conducted with solutions prepared freshly before each test using sucrose dissolved in distilled water. Six concentrations of sucrose (table sugar) will be tasted in random order, with the most concentrated solution being roughly the sweetness of soda.

Start Date: May 24, 2018

Completion Date: May 4, 2019

Status: Recruiting

Effects of Walking and Unilateral Leg Heating on Vascular Function in Diabetic Patients

The notion that habitual aerobic exercise increases insulin-induced vasodilation is largely founded on rodent studies, hence the urgent need for human studies, especially in patients with type 2 diabetes (T2D). For example, it remains unknown if increased walking, the most common form of physical activity, enhances skeletal muscle vasodilator actions of insulin in T2D. In addition, the molecular mechanisms by which exercise improves vasoreactivity to insulin have not been examined in humans.

Start Date: May 1, 2018

Completion Date: June 1, 2022

Status: Recruiting

Alcohol Impaired Driving in the Natural Environment

Despite previous success in reducing alcohol impaired driving (AID) and fatal crashes, rates have not decreased significantly since the 1990s. Developing novel approaches to prevention/intervention are likely required to produce further progress. This project is designed to evaluate a potential intervention for AID using mobile technology. In addition, the project is designed to provide pilot data for a large scale investigation. Recent laboratory work by the PI has demonstrated the utility of assessing AID risk factors when participants are intoxicated.

Start Date: April 2, 2018

Completion Date: January 20, 2019

Status: Recruiting

Low Intensity Physical Activity During Sitting on Glycemic Control and Vascular Function in Obese Individuals

Experimental Design: Twenty obese subjects with metabolic syndrome will complete 2 study days with measures vascular function and glycemic control. On one study day, the subjects will sit quietly for 3 hours and on the second study day subjects will sit quietly for 3 hours and simultaneously move their legs using fidgetting. VISIT 1: All visits will be in Gwynn Hall.

Start Date: March 20, 2018

Completion Date: January 19, 2021

Status: Recruiting

Patients' Perspectives About a Pain Education Video

The long-term goal is to reduce disability in patients with chronic pain by improving communication about pain among patients, caregivers, and health care providers (HCPs). The proposed study addresses the long-term goal by conducting a project that investigates the validation and contradiction of patients' preexisting pain beliefs during pain education.

Start Date: March 19, 2018

Completion Date: September 30, 2018

Status: Recruiting

Intratympanic Steroid for Bell's Palsy

Facial nerve paralysis is due to inflammation surrounding the facial nerve. Current clinical practice guidelines for treatment of facial nerve paralysis recommend a 10 day course of oral steroids +/- oral acyclovir. Treatment should begin within 72 hours of symptom onset. In patients with complete facial paralysis, electrodiagnostic testing should be offered to the patient (1-2). In patients with 90% degeneration on electroneuronography (ENoG) testing, facial nerve decompression may be considered but is not a current recommendation.

Start Date: January 31, 2018

Completion Date: December 31, 2020

Status: Recruiting

A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection

This double-blind (neither researchers nor participants know what treatment participant is receiving) study will evaluate efficacy/safety of pimodivir in combination with SOC treatment versus placebo in combination with SOC treatment in adolescent, adult, and elderly hospitalized participants with influenza A infection.

Start Date: January 3, 2018

Completion Date: May 1, 2020

Status: Recruiting

Durvalumab and Tremelimumab in Treating Patients With Recurrent Stage IV Lung Cancer

PRIMARY OBJECTIVES: I. To evaluate the objective response rate (confirmed and unconfirmed, complete and partial) by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 among patients treated with durvalumab (MEDI4736) plus tremelimumab. SECONDARY OBJECTIVES: I. To estimate the duration of response (DoR) among patients who achieve a complete response (CR) or partial response (PR) (confirmed and unconfirmed) by RECIST 1.1. II.

Start Date: October 2, 2017

Completion Date: April 1, 2022

Status: Recruiting