Paul Santiago, MD, is a neurosurgeon who treats disorders of the spine and spinal cord from the skull base to the sacrum. He has 20 years of experience as a clinician, treating the most complex disorders while also providing expert care for common conditions.

Dr. Santiago is passionate about working with people and helping find solutions to complex problems. His practice achieves both, with a commitment to treat patients the same way he treats his own family.

A family man, Dr. Santiago is married with children and their generous support allows him to commit to being a busy physician. He has learned to coexist with his wife’s dog, and hopes to someday get the big, goofy dog of his dreams. In his free time, he enjoys Venetian-style glass blowing, cooking and working out.

Education & Training

Medical School

Yale University School of Medicine


Neurological Surgery

  • University of Washington School of Medicine


Neurological Surgery

  • University of Washington School of Medicine


Neurosurgery - Spine

  • University of Chicago Pritzker School of Medicine


MU Health Care participates with most major managed care organizations. To find out whether MU Health Care is a participating provider in your insurance plan or network, or for information on co-payments and deductibles, please contact your insurance carrier directly.

Academic Information


Research Profile

Paul Santiago, MD, is a clinician and researcher interested in improving patient outcomes for spinal diseases and treatments. He has conducted research using gene targeting to study spine development as a neurosurgeon who treats routine and complex spine and spinal column disorders in his clinical practice.

Review the CV for Paul Santiago, MD

Research Interests

  • Outcomes for spinal surgery
  • Spinal imaging
  • Spinal cord injury
  • Spinal implants

Areas of Expertise

  • Spinal surgery
  • Disorders of the cervical, thoracic, lumbar and sacral spine
  • Spinal tumors
  • Spinal cord tumors
  • Traumatic injuries to the cervical, thoracic, lumbar and sacral spine