University Hospital
1 Hospital Dr
Columbia, MO

Phone: 573-884-3278

Other Phone Numbers:

Phone: (573) 882-4141

Get Directions

1. University Hospital

1 Hospital Dr
Columbia, MO
Phone: 573-884-3278
Other Phone Numbers:
Phone: (573) 882-4141
View Details
Get Directions




Education & Training

Medical School

University of Geneva


Internal Medicine

  • Hahnemann MCP University


Internal Medicine

  • Brigham and Women's Hospital


American Board of Internal Medicine
American Board of IM - Cardiovascular Disease


MU Health Care participates with most major managed care organizations. To find out whether MU Health Care is a participating provider in your insurance plan or network, or for information on co-payments and deductibles, please contact your insurance carrier directly.

Academic Information



1 Hospital Drive
Columbia, MO 65212
United States

P. 573-884-9080
F. 573-884-1235

Research Interests

  • Interventional cardiology
  • Role of IGF I and its binding proteins in atherosclerosis
  • Mechanisms of muscle wasting

Areas of Expertise

  • Hypertensive vascular remodeling
  • Insulin-like growth factor (IGF-1) biology
  • Atherosclerosis
  • Skeletal muscle wasting

Awards & Honors

  • Best Doctors in America
  • Distinguished Achievement Award of the American Heart Association, Georgia Affiliate
  • Tinsley Harrison Award of the Southern Society of Clinical Investigation
  • Established Investigator Award – American Heart Association
  • Research Career Development Award – National institutions of Health (not accepted)


  • Higashi Y, Sukhanov S, Shai SY, Danchuk S, Tang R, Snarski P, Li Z, Lobelle-Rich P, Wang M, Wang D, Yu H, Korthuis R, Delafontaine P. Insulin-Like Growth Factor 1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E Deficient Mice.  Circulation. 2016; 133:2217-2218.  PMID: 27154724
  • Blackstock CD, Higashi Y, Sukhanov S, Shai SY, Stefanovic B, Tabony AM, Yoshida T, Delafontaine P. Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA. J Biol Chem. 2014; 289(11): 7264-74. PubMed PMID:  24469459
  • Song Y-H, Li Y, Du J, Mitch WE, Rosenthal N, Delafontaine P. Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest. 2005; 115(2): 451–8. PMCID: PMC544037
  • Yoshida T, Huq TS, Delafontaine P. Angiotensin type 2 receptor signaling in satellite cells potentiates skeletal muscle regeneration. J Biol Chem. 2014; 289(38):26239-48. PubMed PMID: 25112871;
  • Yoshida T, Galvez S, Tiwari S, Rezk BM, Semprun-Prieto L, Higashi Y, Sukhanov  S, Yablonka-Reuveni Z, Delafontaine P. Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration. J Biol Chem. 2013; 288(33): 23823-32. PubMed PMID: 23831688;

For a full list of publications, visit: