As a physician-scientist, Dr. Kevin Staveley-O'Carroll has acquired a broad experience in basic, clinical and translational research, with extensive knowledge and skill sets in cellular and molecular mechanisms of cancer biology and immunology. His goal is to translate basic research into clinical practice.

Education & Training

Medical School

University of Oklahoma


General Surgery

  • Johns Hopkins University School of Medicine


Surgical Oncology

  • Johns Hopkins University School of Medicine


American Board of Surgery


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Academic Information

Hugh E. Stephenson Jr., MD, Chair, Department of Surgery
Director of Ellis Fischel Cancer Center

Research Profile

Dr. Staveley-O'Carroll currently is the PI for a phase 2 clinical trial investigating Poly-ICLC in the treatment of solid cancers (NCT02423863). Previously, he served as PI for an investigator-initiated phase 1 trial studying the effects of intra-tumoral injection of Poly-ICLC and adoptively transferred dendritic cells in patients with pancreatic adenocarcinoma (NCT01677962). His ongoing R01 grant is funded by the NIH to elucidate the cellular and molecular mechanisms by which chemotherapeutic agents and nanoparticles, prevent immunotolerance and enhance T cell-mediated immunotherapy. He also serves as a PI on a VA Merit Award investigating the effect of radiofrequency ablation after manipulating the tumor microenvironment in our novel model of murine HCC.

Research Interests

  • Clinical trials
  • Tumor‐induced immunotolerance
  • Liver cancer
  • Pancreatic cancer
  • Immunotherapy
  • Crosstalk of gut microbiome and diet in liver fibrosis and liver cancer
  • Animal tumor models

Areas of Expertise

  • Translational research
  • Immunology
  • Cancer
  • Liver disease