Education & Training

Medical School

University of California at Davis School of Med


  • California Pacific Medical Center


Internal Medicine

  • VA Boston Healthcare System



  • Massachusetts General Hospital


  • Harvard Medical School


American Board of Internal Medicine.
American Board of IM - Cardiovascular Disease


MU Health Care participates with most major managed care organizations. To find out whether MU Health Care is a participating provider in your insurance plan or network, or for information on co-payments and deductibles, please contact your insurance carrier directly.

Academic Information

Director, Center for Precision Medicine
Frances T. McAndrew Chair
Professor, Medicine


1 Hospital Drive
Columbia, MO 65212
United States

P. 573-882-8280
F. 573-884-1235

Research Profile

Grant Support

Principal Investigator, Doxorubicin-induced Cardiotoxicity: the Role of Topoisomerase 2ßβ, 1-R01-HL126916-01, NIH/NHLBI, $1,600,000, 4/1/2015−8/31/2019 
Principal Investigator, Heart Failure with Preserved Systolic Function, Program Project Planning Grant, University of Missouri, $75,000, 3/2018-9/2019

Research Interests

  • Co-discoverer of SUMO/Sentrin in 1996
  • Discovery of NEDD8 in 1997 
  • Discovery of the molecular basis of anthracycline cardiotoxicity in 2012
  • Adult stem cell in cardiac repair
  • Glycosyl-phosphatidylinositol anchor and paroxysmal nocturnal hemoglobinuria

Areas of Expertise

  • Onco-cardiology
  • Molecular mechanism of anthracycline-induced cardiotoxicity
  • SUMO/Sentrin
  • NEDD8

Awards & Honors

  • 1987-1990: Investigator Award, Arthritis Foundation
  • 1987-1990: Upjohn/Massachusetts General Hospital Scholar Award
  • 1992-1999: Established Investigator, American Heart Association
  • 1993: American Society of Clinical Investigation
  • 2000: Association of American Physicians
  • 2001: Distinguished Alumnus Award, U.C. Davis Medical School
  • 2005: Outstanding Advocate Award, American Heart Association-Houston
  • 2006: Academician, Academia Sinica
  • 2007: America’s Top Cardiologists
  • 2007-present: Best Doctors in America
  • 2008: McNair Scholar, Texas Heart Institute
  • 2011: Heart Ball Medical Honoree, American Heart Association-Houston
  • 2012: Lifetime Achievement Award, Society of Chinese Bioscientists in America, Texas Chapter
  • 2016: American Association for the Advancement of Science Fellow


  1. Yeh, E.T., Reiser, H., Bamezai, A., Rock, K.L. (1988). TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor.  Cell, 52:665-674.
  2. DeGasperi, R., Thomas, L., Sugiyama, E., Chang, H.M., Beck, P.J., Orlean, P., Albright, C., Waneck, G., Sambrook, J., Warren, C., and Yeh, E.T.(1990). Correction of a defect in mammalian GPI anchor biosynthesis by a transfected yeast gene.  Science (Wash. D.C.), 250:988-991.
  3. Okura, T., Gong, L., Kamitani, T., Wada, T., Okura, I., C.F. Wei, Chang, H.M., and Yeh, E.T.(1996). Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, Sentrin.  Journal of Immunology (Cutting Edge), 157:4277-4281.
  4. Kamitani, T., Kito, K., Nguyen, H.P., Yeh, E.T.(1997). Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein.  Journal of Biological Chemistry, 272:28557-28562.
  5. Gong, L., Kamitani, T., Millas, S., Yeh, E.T.(2000). Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins.  Journal of Biological Chemistry, 275:14212-14216.
  6. Pasceri, V., Willerson, J.T., Yeh, E.T.(2000). Direct proinflammatory effects of C-reactive protein on human endothelial cells. Circulation, 102:2165-2168.
  7. Cheng, J., Kang, X., Zhang, S., Yeh, E.T.(2007). SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia.  Cell, 131:584-595.
  8. Kang, X., Qi, Y., Zuo, Y., Wang, Q., Zou, Y., Schwartz, R.J., Cheng, J., Yeh, E.T.(2010). SUMO-specific protease 2 is essential for suppression of polycomb group proteins- mediated gene silencing during embryonic development. Molecular Cell, 38(2):191-201.
  9. Dou, H., Huang, C., Singh M., Carpenter P.,Yeh, E.T.(2010). Regulation of DNA Repair through De-SUMOylation and SUMOylation of Replication Protein A Complex.  Molecular Cell, 39(3):333-45.
  10. Nguyen,T.V., Angkasekwinai, P.,Dou, H.,Lin, F.M., Lu, L.S., Cheng, J.,Chin, E., Dong, C., and Yeh, E.T.(2012). SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation. Molecular Cell, 45(2):210-221.
  11. Zhang, S., Liu, X., Bawa-Khalfe, T., Lu, L., Lyu, Y., Liu, L., Yeh, E.T.(2012). Identification of the Molecular Basis of Doxorubicin-Induced Cardiotoxicity.  Nature Medicine, 18(11):1639-42.
  12. Bawa-Khalfe, T., Lu, L., Zuo, Y., Huang, C., Dere, R., Lin, F., Yeh, E.T.(2012). Differential Expression of SUMO-Specific Protease 7 Variants Regulates Epithelial Mesenchymal Transition.  Proceedings of National Academy of Sciences USA, 109(43):17466-17471.
  13. Qi, Y., Wang, J., Bomben, V.C., Li, D.P., Chen S.R., Sun, H., Xi, Y., Reed, J.G., Cheng, J., Pan, H.L., Noebels, J.L. and Yeh, E.T.(2014). Hyper-SUMOylation of the Kv7 Potassium Channel Diminishes the M-Current Leading to Seizures and Sudden Death.  Neuron, 83: 1159-71.
  14. Ritho, J., Arnold, S., Yeh, E.T., (2015). A critical SUMO1-modification of LKB1 regulates AMPK activity during energy stress. Cell Reports, 12:734-742.
  15. Ferdaoussi, M., Dai, X., Jensen, M.V., Wang, R., Peterson, B.S., Huang, C., Ilkayeva, O., Smith, N., Miller, N., Hajmrle, C., Spigelman, A.F., Wright, R.C., Plummer, G., Suzuki, K., Mackay, J.P., van de Bunt, M., Gloyn, A.L., Ryan, T.E., Norquay, L.D., Brosnan, M.J., Trimmer, J.K., Rolph, T.P., Kibbey, R.G., Manning, Fox, J.E., Colmers, W..F, Shirihai, O.S., Neufer, P.D., Yeh, E.T., Newgard, C.B., MacDonald, P.E. (2015). Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.Journal of Clinical Investigation. 125(10):3847-60. (co-corresponding author).
  16. Huang, C., Cheng, J., Bawa-Khalfe, T.,Yao, X, Chin, Y., Yeh, E.T.(2016). SUMOylated ORC2 recruits a histone demethylase to regulate centromeric histone modification and genomic stability. Cell Reports, 15:147-157. 
  17. Yeh, E.T., Chang, H. (2016). Oncocardiology: Past, Present, and the Future, JAMA Cardiology, 1:1066-1072.
  18. Chang, H.M., Moudgil, R., Scarabelli, T., Okwuosa, T., Yeh, E.T., (2017). Cardiovascular complications of cancer therapy.  Part 1, Journal of American College of Cardiology, 70:2536-2551.
  19. Chang, H.M., Okwuosa, T., Scarabelli, T., Moudgil, R., Yeh, E.T., (2017). Cardiovascular complications of cancer therapy.  Part 2, Journal of American College of Cardiology, 70:2552-2565.
  20. Yang, F-M, Zuo, Y., Zhou, W., Xia, C., Hahm, B., Sullivan, M., Cheng, J., Chang, H.M.,  Yeh, E.T., (2018). sNASP inhibits TLR Signaling to regulate Immune Response in Sepsis, Journal of Clinical Investigation, 128:2459-2472.