COVID-19 Vaccine

The key to effectively managing coronavirus is vaccination.

Currently, there are three vaccines authorized for use in the United States to prevent coronavirus disease 2019 (COVID-19). Other vaccines are being developed and are in various stages of the development and testing process.

Photo of COVID-19 vaccine administration


The introduction of vaccines to fight the COVID-19 opens up the path to managing the deadly disease. And by choosing to be vaccinated, you can protect not only yourself and your family but your community as well.

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How do the vaccines work?

The first two authorized vaccines — Pfizer-BioNTech and Moderna — use messenger RNA (mRNA) to instruct the body to build the coronavirus’ signature spike protein. The third authorized vaccine, by Johnson & Johnson, uses DNA inserted into an adenovirus to instruct the body to build the coronavirus’ signature spike protein. Regardless of the technology, the presence of the spike protein prompts an immune system response, resulting in antibodies that can combat the coronavirus.

The Pfizer-BioNTech vaccine requires two doses given 21 days apart. The Moderna vaccine requires two doses given 28 days apart. Data from the clinical trials conducted in adults found the Pfizer-BioNTech vaccine to be 95% effective after two doses and the Moderna vaccine 94.1% effective, meaning they prevented people who got the vaccine from getting COVID-19. Learn more about the mRNA vaccines.

Trials in adolescents ages 12-15 found the Pfizer vaccine to be 100% effective. Learn more about the vaccine in this age group.

The Johnson & Johnson vaccine is a one-dose vaccine. It was shown to be 72% effective against moderate to severe COVID-19 infections in a clinical trial in the United States. Across all regions where it was tested, the vaccine was 85% effective in preventing severe cases COVID-19 at 28 days after vaccination. There were no cases of severe disease reported after Day 49 of the trials. Learn more about the Johnson & Johnson vaccine.

Facts about COVID-19 vaccines:

  • They cannot give you COVID-19.
    • They do not use the live virus that causes COVID-19.
  • They do not affect or interact with your DNA in any way.

Learn the difference between vaccine myths and facts.

Are the vaccines safe?

The vaccines have passed the same rigorous Food and Drug Administration (FDA) standards as other vaccines. They were tested in large clinical trials — made up of tens of thousands of adults of different ages, races, ethnicities and medical conditions — to ensure they meet safety standards.

  • The FDA carefully reviews all safety data from clinical trials and authorizes emergency vaccine use only when the expected benefits outweigh potential risks.
  • The Advisory Committee on Immunization Practices (ACIP) reviews all safety data before recommending any COVID-19 vaccine for use.
  • FDA and Centers for Disease Control and Prevention will continue to monitor the safety of COVID-19 vaccines to ensure even very rare side effects are identified.

You cannot get COVID-19 from the vaccines. Some participants in the trials did report side effects similar to mild symptoms of Coronavirus infection, including muscle pain, chills and a headache. Serious reactions were rare.

How much does the vaccine cost?

The COVID-19 vaccine itself is provided at no charge to you. However, there is a vaccine administration charge that will be billed to your insurance if you are insured. At this time, there is no copay or co-insurance and thus no out-of-pocket costs. You will enter your insurance information (if you are insured) when scheduling your appointment.

For those with Medicare Advantage plans, you will need to know your Medicare Beneficiary Identifier (MBI). Your MBI is on your Medicare card. Learn more.

What if I’ve already had COVID-19?

If you have already had COVID-19, there is evidence that you can still benefit from the vaccine. At this time, experts do not know how long someone is protected from getting sick again after recovering from COVID-19. The immunity someone gains from having an infection, called natural immunity, varies from person to person. Some early evidence suggests natural immunity may not last very long.

See below on timing of when you should consider vaccination.

How to access your vaccine verification

If you received your vaccine through MU Health Care – either at Faurot Field, our Keene Street vaccination site, or through our clinics, pharmacies or hospitals – you can access your vaccine verification through HEALTHConnect, either online or in the app. (Get the app.)

  1. Log in to HEALTHConnect.
  2. Click on Results.
  3. Click on COVID-19 Results.
  4. Click on "View Vaccine Verification" under Covid-19 Vaccine Verification.
  5. You will have the option to print your vaccine verification or scan the QR code to save it on your phone.

Other ways to get your vaccine record

If you were vaccinated at MU Health Care, complete the records authorization form and follow directions on the form to submit to medical records.

Vaccine records also are available from the state of Missouri and can be requested via email or fax. Complete the Missouri Record Request form and email to or fax to 573-526-0238.

More Frequently Asked Questions

Q: Who can get vaccinated?

A: The vaccine is available and strongly encouraged for all adults. The Pfizer vaccine is available for anyone 12 and older. For those 12-17, they must have a parent or guardian sign the vaccine consent form. Schedule your appointment.

Learn about booster shots.

Q: If I’ve had COVID-19, how long do I need to wait to get vaccinated?

A: The Advisory Committee on Immunization Practices recommends that people wait until they’ve recovered and have completed the isolation period. For most people, that is 10 days after symptom onset and at least 24 hours without fever. For people with no symptoms, isolation can be discontinued 10 days after the first positive test.

Because reinfection is uncommon within 90 days of infection and vaccine supply currently is limited, people with documented acute infection are OK to delay the vaccine for 90 days if they choose.

If you are infected between your first and second doses, you should consult with your health care provider and consider getting the second dose after completing the isolation period. You should not wait 90 days because it’s unknown how that long of a delay would impact the vaccine’s effectiveness.

Q: If I received an antibody treatment or convalescent plasma can I get the vaccine?

A: Anyone who received monoclonal antibody or convalescent plasma treatment for COVID-19 should wait 90 days before getting vaccinated. This precautionary delay is recommended because it’s unclear if the treatment would interfere with the vaccine-induced immune response.

Q: If I have had Multisystem Inflammatory Syndrome (adult or child), should I get the vaccine?

A: People with a history of Multisystem Inflammatory Syndrome in Children (MIS-C) or in adults (MIS-A) should consider delaying vaccination until they have recovered from illness and for 90 days after the date of diagnosis.

Q: If I get the vaccine, do I still have to wear a mask?

A: Although you are now protected from infection and can enjoy some things you weren’t able to do over the past year, experts advise it is important to continue following mask and distancing guidelines in public until a sufficient proportion of the population joins you in the ranks of the vaccinated. Learn more about what you can do once you're fully vaccinated.

Q: How long will I have immunity after getting a vaccine, and will it last longer than immunity from having the disease?

A: Because this virus is new, we don’t know how long immunity lasts — either for infection or vaccination. It is thought that immunity lasts at least six months.

Learn about booster shots.

Q: Should I wait after getting another vaccine to receive a COVID-19 vaccine?

A: Consistent with CDC guidelines, there is no need to wait to receive the COVID-19 vaccine if you have received another vaccination.

Q: What are common reactions to the vaccine?

A: Most reactions are mild to moderate and are similar to side effects seen with other immunizations. These can include fever, soreness at the injection site, or even a temporary flu- like feeling with muscle aches, headache or fatigue.

Q: What if I have a reaction to the vaccine?

A: Some people might develop temporary flu-like symptoms, including fever, shortly after the second dose. This reaction is not an infection or sickness but is part of the immune system’s reaction to “seeing” the proteins from the vaccine.

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